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  • 标题:Effect of Procainization of Ventromedial Nucleus of Hypothalamus on the Feeding Behavior of Rats
  • 本地全文:下载
  • 作者:Rajesh Yadav ; Manjula Suri ; Rashmi Mathur
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:2009
  • 卷号:44
  • 期号:3
  • 页码:247-252
  • DOI:10.3164/jcbn.08-158
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:Bilateral lesions in the Ventromedial nucleus of hypothalamus (VMH) cause hyperphagia and a preference for high lipid, high carbohydrate diet. Reversible lesion by procaine microinfusion produces a decrease in serum glucose and immunoreactive insulin levels. In the present study the effect of procaine microinfusion on feeding behavior and taste preference was observed. 5 h and 24 h food intake, water intake and weekly body weight of the rats was measured. Three bottle preference test was used to study the diet preferences. The 24 h food intake was found to be significantly more on 1st, 2nd and 3rd day (41 ± 6.03, 38.83 ± 6.17 and 33.66 ± 5.88 g/day, respectively) of procaine injection. There was also a significant increase in food intake at 0.25 h (4.166 ± 2.04 g) and 1 h (5 ± 0 g) as compared to saline group (0 ± 0 g at 0.25 h and 0.83 ± 2.04 g at 1 h). Post procaine water intake and body weight for seven days was not statistically significantly when compared to pre-lesion values. In the three bottles preference test, after procaine microinfusion there was a significantly increased preference for 20% sucrose and 0.15% saccharin than quinine and citric acid. The results suggest that bilateral procainization of VMH produces a transient increase in food intake and enhance preference for sweet tasting substances.
  • 关键词:food intake;water intake;body weight;preference;lesion
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