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  • 标题:Genome-Scale Approaches to Investigate Oxidative DNA Damage
  • 本地全文:下载
  • 作者:Shinya Akatsuka ; Shinya Toyokuni
  • 期刊名称:Journal of Clinical Biochemistry and Nutrition
  • 印刷版ISSN:0912-0009
  • 电子版ISSN:1880-5086
  • 出版年度:2010
  • 卷号:47
  • 期号:2
  • 页码:91-97
  • DOI:10.3164/jcbn.10-38R
  • 出版社:The Society for Free Radical Research Japan
  • 摘要:In the trend of biological science after the completion of the human genome project, appreciation of an organism as a system rather than the sum of many molecular functions is necessary. On the investigation of DNA damage and repair, therefore, the orientation toward systematic and comprehensive genome-scale approaches is rapidly growing. The immunoprecipitation-based technique combined with high-density microarrays is one of the promising methods to provide access to such novel research strategies. We propose this sort of research area as oxygenomics.
  • 关键词:DNA immunoprecipitation;8-oxoguanine;acrolein-modified adenine;chromosome territory;oxygenomics
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