期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2011
卷号：49
期号：1
页码：62-66
DOI：10.3164/jcbn.10-129
出版社：The Society for Free Radical Research Japan
摘要：This study aimed to examine the association of dietary vitamin intakes with plasma pro-inflammatory cytokine levels in Korean heart failure patients. Stable outpatients with heart failure were recruited and finally 91 patients were included. Dietary intakes were estimated by a developed semi-quantitative food frequency questionnaire. The simultaneous measurement of 17 cytokines was performed along with analysis of plasma C-reactive protein. Plasma C-reactive protein levels significantly correlated with dietary intakes of vitamin C ( r = −0.30, p <0.005), β-carotene ( r = −0.23, p <0.05), and folate ( r = −0.31, p <0.005). However, these associations were no longer significant after adjusting for traditional risk factors for heart failure. On the other hand, plasma levels of monocyte chemoattractant protein-1 significantly correlated with dietary folate intake ( r = −0.31, p <0.001), and plasma interleukin-8 levels significantly correlated with dietary intakes of vitamin C ( r = −0.38, p <0.001), β-carotene ( r = –0.42, p <0.001), and folate ( r = −0.38, p <0.001) after the adjustment. Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 ( p <0.005, R2 = 0.20) and interleukin-8 ( p <0.001, R2 = 0.32) through a stepwise multiple linear regression analysis. Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure.
