期刊名称：Journal of Clinical Biochemistry and Nutrition
印刷版ISSN：0912-0009
电子版ISSN：1880-5086
出版年度：2012
卷号：50
期号：2
页码：158-161
DOI：10.3164/jcbn.11-66
出版社：The Society for Free Radical Research Japan
摘要：D -Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D -psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute toxicity testing in rats, D -psicose is classified as an ordinary substance (LD50 = 16 g/kg). Elucidating the effects of sub-chronic feeding of D -psicose in rats is essential before it can be utilized as a physiologically functional food. In this study, male Wistar rats (3 weeks old) were fed diets containing 3% D -psicose or sucrose for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the sucrose and the D -psicose groups. The weights of the liver and kidneys were significantly higher in the D -psicose group than in the sucrose group. However, no gross pathological findings were evident at dietary doses of 3% D -psicose or were correlated with hypertrophy of the liver and kidney. In a clinical chemistry analysis, the erythrocyte and leukocyte courts were significantly higher in the D -psicose group, but that was not considered to be toxicologically significant. Therefore, the present study found no adverse effects of D -psicose in rats fed a diet containing 3% D -psicosefor 90 days.
