摘要：SummaryVinylboron compounds are important compounds in organic chemistry and biology. In this communication, we developed a copper(I)-catalyzed, highly regio- and stereoselective radicaltrans-hydroboration of ynamides withN-heterocyclic carbene (NHC)-ligated borane is reported, which leads to a series oftrans-boryl enmides that can be conveniently transformed into various multi-substituted enamides. Further investigation showcased that our method is robust and scalable. The mechanism of this unique reaction is studied and discussed.Graphical abstractDisplay OmittedHighlights•A Cu-catalyzed highly regio- and stereoselective radicaltrans-hydroboration of ynamides•Good to excellent yields, good functional group tolerance•Further investigation showcased that our method is robust and scalableCatalysis; Organic chemistry; Organic synthesis
