摘要：SummaryD-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Here, we report a strategy to incorporate multiple reaction sites on a chiral 1,1′-bi-2,2′-naphthol-based fluorescent probe. It can respond specifically to D-arginine, while producing no response when in contact with all other amino acids. The probe can report arginine’s concentration, and enantiomeric configuration and colorimetric studies enable its qualitative determination.Graphical abstractDisplay OmittedHighlights•A new strategy to form a fluorescent probe (S)-3with multiple reaction sites•Specific response to D-arginine among 39 chiral amino acids•Metal-free detection, quick responses within a minute•Qualitative determination of arginine through colorimetric studiesChemistry; Analytical chemistry; Analytical chemistry applications.
