摘要：SummaryTime-restricted eating (TRE) is known to improve metabolic health, whereas very few studies have compared the effects of early and late TRE (eTRE and lTRE) on metabolic health. Overweight and obese young adults were randomized to 6-h eTRE (eating from 7 a.m. to 1 p.m.) (n = 21), 6-h lTRE (eating from 12 p.m. to 6 p.m.) (n = 20), or a control group (ad libitumintake in a day) (n = 19). After 8 weeks, 6-h eTRE and lTRE produced comparable body weight loss compared with controls. Compared with control, 6-h eTRE reduced systolic blood pressure, mean glucose, fasting insulin, insulin resistance, leptin, and thyroid axis activity, whereas lTRE only reduced leptin. These findings shed light on the promise of 6-h eTRE and lTRE for weight loss. Larger studies are needed to assess the promise of eTRE to yield better thyroid axis modulation and overall cardiometabolic health improvement.Graphical abstractDisplay OmittedHighlights•6-h eTRE and lTRE regimens were evaluated in 60 overweight and obese young adults•The duration from the last meal to the measurement for eTRE is much longer than lTRE•Both regimens produce similar body weight loss over the 8 weeks of the study•ETRE, but not lTRE, reduced blood pressure, mean glucose, and insulin resistanceHealth sciences; Obesity medicine; Human metabolism
