摘要：SummaryDeterminants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+and CD8+T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+T cell subsets are associated with longevity and antibody responses.Graphical abstractDisplay OmittedHighlights•Th17-like CD4+T cells showed a longer half-life than other CD4+T cell subsets•Anti-RBD-IgG titers were associated with Th2- and Tfh-like CD4 T cells•CD45RA+CD8+T cells were correlated with disease severity during the early phaseHealth sciences; Medicine; Immunology; Virology; Biological sciences; Immunology; Virology.
