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  • 标题:Comprehensive spectral libraries for various rabbit eye tissue proteomes
  • 本地全文:下载
  • 作者:Guoting Qin ; Pengzhi Zhang ; Mingxia Sun
  • 期刊名称:Scientific Data
  • 电子版ISSN:2052-4463
  • 出版年度:2022
  • 卷号:9
  • 期号:1
  • 页码:1-6
  • DOI:10.1038/s41597-022-01241-5
  • 语种:English
  • 出版社:Nature Publishing Group
  • 摘要:Rabbits have been widely used for studying ocular physiology and pathology due to their relatively large eye size and similar structures with human eyes . Various rabbit ocular disease models, such as dry eye, age-related macular degeneration, and glaucoma, have been established . Despite the growing application of proteomics in vision research using rabbit ocular models, there is no spectral assay library for rabbit eye proteome publicly available . Here, we generated spectral assay libraries for rabbit eye compartments, including conjunctiva, cornea, iris, retina, sclera, vitreous humor, and tears using fractionated samples and ion mobility separation enabling deep proteome coverage . The rabbit eye spectral assay library includes 9,830 protein groups and 113,593 peptides . We present the data as a freely available community resource for proteomic studies in the vision feld . Instrument data and spectral libraries are available via ProteomeXchange with identifer PXD031194 .
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