摘要：The acute efects of anesthesia and their underlying mechanisms are still not fully understood . Thus, comprehensive analysis and efcient generalization require their description in various brain regions . Here we describe a large-scale, annotated collection of 2-photon calcium imaging data and multi- electrode, extracellular electrophysiological recordings in CA1 of the murine hippocampus under three distinct anesthetics (Isofurane, Ketamine/Xylazine and Medetomidine/Midazolam/Fentanyl), during natural sleep, and wakefulness . We cover several aspects of data quality standardization and provide a set of tools for autonomous validation, along with analysis workfows for reuse and data exploration . The datasets described here capture various aspects of neural activity in hundreds of pyramidal cells at single cell resolution . In addition to relevance for basic biological research, the dataset may fnd utility in computational neuroscience as a benchmark for models of anesthesia and sleep .
