摘要：Two isoforms of brain ankyrin, 440 kD and 220 kD ankyrinB, and neuronal cell adhesion molecule L1, which can bind to brain ankyrin, are both expressed in human neuroblastoma NB-1 cells. To examine the potential importance of the interaction between brain ankyrins and L1 in neuronal cell functions, an expression vector encoding a cytoplasmic domain of L1 has been constructed and transfected in NB-1 cells. The results obtained show that the expressed L1 cytoplasmic domain is ineffective in perturbing the interaction between brain ankyrins and L1, possibly because it exists in a monomeric form.
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