文章基本信息

标题：Testicular Toxicity of Mono-n-Butyl Phthalate and Related Phthalates on Bound Iron in Rat Red Blood Cells
作者：Nobuo Watanabe ; Makiko Shimizu ; Yoshiaki Matsumoto 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2002
卷号：48
期号：6
页码：527-533
DOI：10.1248/jhs.48.527
出版社：The Pharmaceutical Society of Japan
摘要：It was previously reported that free iron was released from rat red blood cells in both an in vitro study with a metabolite, mono- n -butylphthalate (MBP), of di- n -butylphthalate (DBP) and an in vivo study with oral DBP, inducing rat testicular atrophy in hypoxic conditions due to MBP-induced hemoglobin deprivation. This study investigated whether mono- n -alkylphthalates (alkyl-carbon C₄-C₆ ; MAP), which result in rat testicular damage, induce iron release from hemoglobin by incubation with rat red blood cells. Iron release was observed with C₃-C₆ MAP incubation at lower doses and with C₁ and C₂ MAP incubation at higher doses, but not with C₇, C₈, and C₄₍₆₎ MAP.
关键词：di-n-butylphthalate;mono-n-alkylphthalate;testicular damage;hemoglobin;hypoxia