Biochemical changes that occurred in the blood of myocardial infarction patients were investigated. Two hundred and fifty two patient, 180 males and 72 females were involved in this study. The mean age was 49.3 ± 9.25 years. Biochemical parameters including serum total protein, albumin, total bilirubin, and total cholesterol to albumin ratio were analyzed. Biochemical parameters showed that the increased level of triglyceride and total bilirubin were associated with myocardial infarction. Triglyceride and total bilirubin levels in myocardial infarction patients were 2.3 ± 1.4 mmol/l and 12.3 ± 3.2 μ mol/l respectively, whereas those of healthy controls were 1.7 ± 1.2 mmol/l for triglyceride and 9.7 ± 3.7 μ mol/l for bilirubin. On the other hand, serum total protein and albumin concentrations were lower in myocardial infarction patients compared with those of controls. Total protein level was 65.5 ± 3.1 g/l in myocardial infarction patients and 76.2 ± 5.3 g/l in healthy controls. Albumin levels in both patients and controls were 40.2 ± 3.2 g/l and 45.4 ± 4.5 g/l correspondingly. Interestingly, serum total cholesterol level was not significantly different in myocardial infarction patients compared with controls. Patients cholesterol level was 5.8 ± 1.3 mmol/l and that of controls was 5.2 ± 1.2 mmol/l. In addition, cholesterol/albumin ratio in infarction patients (0.14 ± 0.04) found to be significantly higher than that in healthy controls (0.11 ± 0.03).