文章基本信息

标题：Protective Effects of (-)Epigallocatechin Gallate and (+)Catechin on Nitrogen Oxide-Induced Sister Chromatid Exchange
作者：Reiko Tanaka
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：2005
卷号：51
期号：1
页码：89-92
DOI：10.1248/jhs.51.89
出版社：The Pharmaceutical Society of Japan
摘要：The protective effects of green tea polyphenols on nitrogen oxide (NOx)-induced sister chromatid exchange (SCE) in cultured cells were studied. (-)Epigallocatechin gallate (EGCG) and (+)catechin (CT), the major polyphenol constituents of green tea, were found to reduce the frequency of SCE induced by NOx. NO releaser (NOR4)-released NO and NaNO₂ were used as NOx. Significantly fewer SCEs were induced by 30 μ M NOR4 and NaNO₂ after the treatment of cells with 0.1 μ M EGCG or 0.5 μ M CT. NOx (NO, NO₂^-) is a potent environmental pollutant owing to its carcinogenic properties. Therefore these experimental results indicate the protective effects of green tea against NOx-type carcinogens.
关键词：green tea;nitrogen oxide;sister chromatid exchange;(-)epigallocatechin gallate;(+)catechin