摘要：To determine the effects of optical isomerism on the estrogenic activity of 4-nonylphenol (NP) isomers, four optically active NP isomers, (3 R )-4-(3-ethyl-2-methylhexan-2-yl)phenol, (3 S )-4-(3-ethyl-2-methylhexan-2-yl)phenol, (4 R )-4-(2,4-dimethylheptan-4-yl)phenol and (4 S )-4-(2,4-dimethylheptan-4-yl)phenol, were prepared and separated using chiral HPLC. Their absolute configurations were elucidated by X-ray crystallographic analysis of their bromobenzoylated derivatives. The estrogenic activities (recombinant yeast screen assay) of the optically active NPs were similar to those of the corresponding racemates.
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