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文章基本信息

  • 标题:Nuclear Factor κB Inhibition by Dibenzoylmethane Derivatives
  • 作者:Nobuyasu Matsuura ; Rika Murakami ; Tomoyuki Katayama
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:2009
  • 卷号:55
  • 期号:2
  • 页码:311-313
  • DOI:10.1248/jhs.55.311
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:We established stable HeLa transformants with reporter genes containing nuclear factor (NF)-κB response elements to measure NF-κB inhibition. Tumor necrosis factor (TNF)- α treatment induced a 6-fold activation of NF-κB in HeLaNF-κB-3 cells. Three chloro-derivatives of fourteen dibenzoylmethane derivatives inhibited NF-κB activity.
  • 关键词:nuclear factor κB;dibenzoylmethane derivative;inhibitor;stable transformant
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