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  • 标题:Effect of Momordica charantia on Adenosine Monophosphate-activated Protein Kinase in Genetically Type 2 Diabetic Mice Muscle
  • 本地全文:下载
  • 作者:Toshihiro Miura ; Takanori Kawata ; Satoshi Takagi
  • 期刊名称:Journal of Health Science
  • 印刷版ISSN:1344-9702
  • 电子版ISSN:1347-5207
  • 出版年度:2009
  • 卷号:55
  • 期号:5
  • 页码:805-808
  • DOI:10.1248/jhs.55.805
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:The hypoglycemic activity of Momordica charantia L. (Cucurbitaceae) (MC) was investigated in KK-Ay mice, an animal model of type 2 diabetes. The water extract of the fruit of MC (100 mg/kg) reduced the blood glucose of KK-Ay mice 2 and 4 hr after oral administration ( p <0.05). In addition, the muscle adenosine monophosphate-activated protein kinase (AMPK) was significantly activated in the orally MC-treated mice when compared to that of the controls ( p <0.01). These results suggest that the antidiabetic effect of MC is derived, at least in part, from an activation of AMPK in the muscle.
  • 关键词:adenosine monophosphate-activated protein kinase;hypoglycemic effect;KK-Ay;Momordica charantia;Cucurbitaceae
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