摘要：We investigated the preventive effects of a saccharified solution of rice, Oryza sativa subsp. japonica , against type IV and type I allergy in mice. The oral and/or percutaneous administration of the saccharified rice solution prevented type IV allergy at doses of 0.3 and 0.5 ml/mouse and at a dose of 10 μl/ear, respectively. With oral administration, the solution also suppressed type I allergy at doses of 0.25 and 0.5 ml/mouse. In the case of type IV allergy, administration of the saccharified rice solution suppressed the ear levels of tumor necrosis factor-α and tended to suppress the ear levels of interleukin-12. The non-dialysate prepared from the saccharified solution showed similar effects to the original solution, suggesting that the molecular weights of the active components are higher than ca . 14000. The saccharified rice solution also enhanced the antioxidative activities in the serum of mice with type IV allergy. These results suggest that the saccharified rice solution may be a convenient beneficial food material for prevention of allergies based on suppression of the increases in some proinflammatory cytokines and promotion of antioxidative activity.
关键词：rice;mouse;type IV allergy;type I allergy;cytokine
