摘要：Graphical abstractDisplay OmittedAbstractBackgroundLight at night (LAN) may alter estrogen regulation through circadian disruption. High levels of outdoor LAN may increase breast cancer risk, but studies have largely not considered possible residual confounding from correlated environmental exposures. We evaluated the association between indoor and outdoor LAN and incident breast cancer.MethodsIn 47,145 participants in the prospective Sister Study cohort living in the contiguous U.S., exposure to outdoor LAN was determined using satellite-measured residential data and indoor LAN was self-reported (light/TV on, light from outside the room, nightlight, no light). We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between outdoor and indoor LAN and breast cancer risk. Models were adjusted for age, race/ethnicity, educational attainment, annual household income, neighborhood disadvantage, latitude, and population density as a proxy for urbanicity. To evaluate the potential for residual confounding of the outdoor LAN and breast cancer relationship by factors associated with urbanicity, we considered further adjustment for exposures correlated with outdoor LAN including NO2[Spearman correlation coefficient, rho (ρ) = 0.78], PM2.5(ρ = 0.36), green space (ρ = − 0.41), and noise (ρ = 0.81).ResultsDuring 11 years of follow-up, 3,734 breast cancer cases were identified. Outdoor LAN was modestly, but non-monotonically, associated with a higher risk of breast cancer (Quintile 4 vs 1: HR = 1.10, 95% CI: 0.99–1.22; Quintile 5 vs 1: HR = 1.04, 95% CI: 0.93–1.16); however, no association was evident after adjustment for correlated ambient exposures (Quintile 4 vs 1: HR = 0.99, 95% CI: 0.86–1.14; Quintile 5 vs 1: HR = 0.89, 95% CI: 0.74–1.06). Compared to those with no indoor LAN exposure, sleeping with a light or TV on was associated with a HR = 1.09 (95% CI: 0.97–1.23) in the adjusted model.ConclusionsOutdoor LAN does not appear to increase the risk of breast cancer after adjustment for correlated environmental exposures.
关键词：KeywordsBreast cancerLight at nightEnvironmental epidemiologyProspective cohort
