With the Profile of Mood States (POMS), a German version of an international instrument for the assessment of mood is available. The paper introduces a new short version containing 24 items and four scales. In a study about indoor climate in 4596 office workers only a few missing values were noted. Psychometric analyses showed very good characteristics of the four scales regarding their internal consistency (Cronbach’s α) and scale fit. High floor effects indicated a limited exhaustion of the scale range. Age and gender effects of the scale scores concerned the scales “vigour” and “fatigue”. Furthermore, the scales of the POMS discriminated between groups with different self-reported disease incidences. A less beneficial characteristic of the POMS could be noted in terms of a high correlation of the scales “numbness” and “fatigue". With the tested version of the POMS, a short instrument with good psychometric properties has been presented which can be assessed in healthy as well as in health-impaired persons.