标题：Comparison of Body Fat Distribution and Blood Lipid Profiles according to Trp64Arg Polymorphism for the β3-Adrenergic Receptor Gene in Korean Middle-Aged Women
期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2006
卷号：52
期号：4
页码：281-286
DOI：10.3177/jnsv.52.281
出版社：Center for Academic Publications Japan
摘要：The aim of this study was to determine whether there was an association between body fat distribution, blood lipid profiles, and β3-adrenergic receptor gene polymorphism in Korean middle-aged women. Subjects were grouped according to BMI as obese (≥25 BMI, n =95) or non-obese (BMI<25, n =93). The Trp64Arg mutation of the β3-adrenergic receptor gene was detected by PCR-RFLP. Skinfold thickness, body circumference, intra-abdominal fat area by CT, and blood lipid profiles were also measured. Data were compared using ANOVA, Bonferroni t -test, and Chi-square. Significance for statistical analyses were set at p <0.05. In the obese group, 63.16% were Trp64Trp homozygotes and 36.84% were Trp64Arg heterozygotes, compared to 80.65% who were Trp64Trp homozygotes and 19.35% who were Trp64Arg heterozygotes in the non-obese group. These results indicated a significant ( x 2=4.943, p <0.05) difference between the two groups. Frequency of the Arg64 allele in the obese group (16.84%) showed a significant ( x 2=4.185, p <0.05) difference as compared to the non-obese group (9.68%). Skinfold thickness and body circumference of the Trp64Arg heterozygote group showed a consistent increase as compared to the Trp64Trp homozygote group. Visceral fat area and VSR of Trp64Arg heterozygote group showed a higher tendency than Trp64Trp homozygotes in the obese group, but these differences were not statistically significant. In conclusion, the Trp64Arg polymorphism of the β3-adrenergic receptor gene is associated with obesity in middle-aged Korean women, but it is difficult to suggest the prominent association of the Trp64Arg polymorphism of the β3-adrenergic receptor gene with prevalence of abdominal obesity or dyslipidemia in Korean middle-aged women.
关键词：obesity;β3-adrenergic receptor gene;Trp64Arg polymorphism;body fat distribution
