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  • 标题:Protease-Resistant Fraction of Smoked, Dried Bonito Alleviates Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice
  • 本地全文:下载
  • 作者:Junichi MATSUMOTO ; Shinpei ISHIKAWA ; Mikiharu DOI
  • 期刊名称:Journal of Nutritional Science and Vitaminology
  • 印刷版ISSN:0301-4800
  • 电子版ISSN:1881-7742
  • 出版年度:2007
  • 卷号:53
  • 期号:5
  • 页码:451-456
  • DOI:10.3177/jnsv.53.451
  • 出版社:Center for Academic Publications Japan
  • 摘要:The effect of smoke-dried bonito undigested fraction remaining after microbial protease treatment (SDBR) on a spontaneously occurring mouse model of atopic dermatitis was studied in male 5-wk-old, NC/Nga mice. Smoke-dried bonito, Katsuobushi, is a traditional Japanese food. SDBR contains 2 major components: bonito oil and protease-undigested proteins. Mice were fed a casein diet containing corn oil (C diet) or a diet containing SDBR (SDBR diet) for 18 wk. In comparison with the C diet, the SDBR diet alleviated the increase in skin severity score and plasma IgE concentration in a time-dependent manner, and lowered leucotriene B4 (LTB4)-releasing ability upon calcium ionophore A23187 stimulation. The SDBR diet did not affect scratching time. These results demonstrate that SDBR diet alleviates atopic dermatitis-like skin lesions in NC/Nga mice.
  • 关键词:protease-resistant fraction of smoke-dried bonito;atopic dermatitis-like skin lesions;IgE;LTB4;NC/Nga mice
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