期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2008
卷号：54
期号：3
页码：250-254
DOI：10.3177/jnsv.54.250
出版社：Center for Academic Publications Japan
摘要：Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B2C1 preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or β-catenin, which inhibit the expression of Glut4, PPARγ and C/EBPα. The compound reduced the expression time of C/EBPβ and C/EBPδ. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARγ or C/EBPα because of the reduced expression time of C/EBPβ and C/EBPδ.
关键词：Grifola frondosa (maitake);bioactive compound;adipocyte;CCAAT/enhancer binding protein (C/EBP);mechanism regulation
