期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2008
卷号：54
期号：3
页码：269-271
DOI：10.3177/jnsv.54.269
出版社：Center for Academic Publications Japan
摘要：We previously suggested in the in vitro mouse jejunum that when the primary epithelial barrier on the villi was largely disabled, a secondary mucosal barrier substitutes for the primary one. This study showed that the mucosal Ca2+ removal did not further deteriorate the histology but increased transmural conductance and lucifer yellow flux, and decreased forskolin-induced potential difference. It is suggested that in this injury model the postulated secondary barrier is Ca2+-dependent and likely to be present on or immediately beneath the mucosal surface.
关键词：paracellular pathway;tight junction;Ca2+-dependent barrier;injury model
