期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2008
卷号：54
期号：5
页码：392-395
DOI：10.3177/jnsv.54.392
出版社：Center for Academic Publications Japan
摘要：The aim of present study was to assess the association between serum zinc and oxidant/antioxidant status in children with protein energy malnutrition. Serum zinc, total antioxidant capacity and malondialdehyde were measured spectrophotometrically in 100 children (6 mo to 5 y); out of these, 50 children were malnourished and 50 children served as controls. Serum zinc levels were found to be significantly low in the malnourished ( p <0.001). Serum zinc levels in Grade I and Grade II malnourished were 82.7 and 67.7 μg/dL respectively and in Grade III and IV combined was 53.2 μg/dL as compared to 109.5 μg/dL in the control group. These levels were significantly lower in children who had skin lesions than in those without such lesions ( p <0.001). Total antioxidant capacity was found to be significantly lowered in malnourished children (Grade I=1.3 mmol/L, Grade II=1.1 mmol/L, Grade III and IV=0.5 mmol/L) as compared to 2.0 mmol/L in the control group ( p <0.001). The malondialdehyde concentration in malnourished children was significantly higher ( p <0.001) (Grade I=1.6 nmol/mL, Grade II=1.9 nmol/mL, Grade III and IV=2.9 nmol/mL) as compared to 1.3 nmol/mL in controls. Total antioxidant capacity and hypoalbuminaemia were also correlated positively with low serum zinc level. Serum trace element deficiency leading to depleted antioxidant protection may be a contributing factor to the pathophysiology of protein energy malnutrition and replacement of these elements in the management of this condition might be important.
关键词：zinc;total antioxidant capacity;malondialdehyde;protein energy malnutrition
