期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2008
卷号：54
期号：6
页码：430-434
DOI：10.3177/jnsv.54.430
出版社：Center for Academic Publications Japan
摘要：Background: Despite long-standing iodine supplementation in Iran, the prevalence of goiter remains high in some areas. This suggests other nutritional deficiencies may be considered as responsible factors for goiter persistence. In the present study we investigated the possible role of vitamin A deficiency (VAD) and low vitamin A status in the etiology of endemic goiter in Semirom, Iran. Materials and Methods: In this cross-sectional study, 1,828 students from 108 primary schools of urban and rural areas of Semirom were selected by multistage random cluster sampling. Thyroid size was estimated in each child by inspection and palpation. Urinary iodine concentration (UIC) and serum retinol (SR) were measured. Results: Overall, 36.7% of schoolchildren had goiter. The median UIC was 18.5 μg/dL. The mean±SD of SR in goitrous and nongoitrous children was 38.84± 10.98 and 39.17±10.85 μg/dL respectively ( p =0.82). There were two children with VAD (SR less than 20 μg/dL); one in the goitrous and one in the nongoitrous group. The prevalence of subjects with low vitamin A status (SR less than 30 μg/dL) in the goitrous and nongoitrous groups was 26.2 and 21.5% respectively ( p =0.42). Conclusion: Goiter is still a public health problem in this region. Iodine deficiency, VAD or low vitamin A status is not among the contributors of goiter persistence in schoolchildren of Semirom. The role of other micronutrient deficiencies or goitrogens should be investigated.
关键词：goiter;iodine deficiency;vitamin A deficiency;low vitamin A status
