期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2009
卷号：55
期号：5
页码：423-427
DOI：10.3177/jnsv.55.423
出版社：Center for Academic Publications Japan
摘要：Previous studies have demonstrated that fatty acid oxidation in the liver may affect food intake. This study examined the influence of preloading of medium-chain triacylglycerol (MCT) on food intake in comparison with long-chain triacylglycerol (LCT). Male rats were fasted for 18 h and then administered LCT or MCT emulsion orally. Each group of rats was allowed to rest for 30 min, and then food intake during 1 h was measured. Food intake in the MCT group was significantly lower than that in the LCT group. To examine the influence of hepatic oxidation, the MCT+MA group was injected intraperitoneally with mercaptoacetate (MA), an inhibitor of fatty acid oxidation, 2 h before ingestion of MCT emulsion. Then, 30 min after ingestion of LCT or MCT emulsion, food intake was measured for 1 h. Food intake in the MCT group was significantly lower than that in the LCT group, but there was no significant difference between the MCT+MA group and the LCT group. Food intake in the MCT+MA group was significantly higher than that in the MCT group. The hepatic ATP content after MCT ingestion was significantly higher than that after LCT ingestion, but there was no significant difference between the MCT+MA group and the LCT group. The hepatic ATP content after MCT+MA ingestion was significantly lower than that after MCT ingestion. These results suggest that ingestion of medium-chain fatty acid (MCFA) increases the liver ATP content in fasted rats, consequently decreasing food intake.
关键词：medium-chain triacylglycerols;food intake;fatty acid oxidation;hepatic ATP content
