期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2012
卷号：58
期号：4
页码：297-302
DOI：10.3177/jnsv.58.297
出版社：Center for Academic Publications Japan
摘要：The purpose of this study was to determine whether ornithine affects the rate of tissue protein synthesis in male rats. Two experiments were done on five or two groups of young rats (5 wk) given diets containing 0.15, 0.3, 0.5 or 0.7% ornithine-HCl added to a 20% casein diet for 1 d (only one 3 h period) (Experiment 1), and given a diet containing 0 or 0.7% ornithine-HCl added to a 20% casein diet for 10 d (Experiment 2). The plasma concentration of growth hormone (GH) was the highest in rats fed 0.5 and 0.7% ornithine added to the 20% casein diet. The fractional rates of protein synthesis in brain regions, liver and gastrocnemius muscle increased significantly with the 20% casein+0.7% ornithine diet compared with the 20% casein diet. In brain regions, liver and gastrocnemius muscle, the RNA activity [g protein synthesized/(g RNA·d)] significantly correlated with the fractional rate of protein synthesis. The RNA concentration (mg RNA/g protein) was not related to the fractional rate of protein synthesis in any organ. The present results suggest that the treatment of young rats with ornithine is likely to increase the concentration of plasma GH and the rate of protein synthesis in the tissues, and that RNA activity is at least partly related to the fractional rate of tissue protein synthesis.
