摘要：This cohort study investigated the association between liver dysfunction and two types of impaired glucose metabolism, i.e., hyperglycemia (HG) and quasidiabetes mellitus (quasi-DM)(quasi-DM was treated as a subset of HG). Accordingly, the study consists of a quasi-DM study and an HG study. Study subjects were middle-aged male workers at printing and paper-making plants who participated in both 1993 and 1997 annual health checkups. In the quasi-DM study, the number of subjects was 1, 422. A logistic regression model revealed that live dysfunction (AST>40IU/l and/or ALT>40IU/l and/or GGT>80IU/l) and obesity (BMI>=25 kg/m2) in 1993 were associated with an increased risk of having quasi-DM in 1997 (odds ratio (OR) for liver dysfunction = 2.1, 95% confidence interval (CI): 1.1-4.1; OR for obesity = 2.0, 95%CI: 1.0-4.0). For alcohol intake, the relationship was positive for former drinkers and negative for current drinkers (for former drinkers, OR=2.7, 95%CI: 0.86-8.6, and for current drinkers, OR=0.39, 95%CI:0.19-0.81). Age and smoking status did not show a meaningful association. In the HG study, the number of subjects was 1, 254. In an analysis identical to that of the quasi-DM study, we found that liver dysfunction and obesity in 1993 was associated with an increased risk of having HG in 1997 (for liver dysfunction, OR=1.8, 95%CI: 1.2-2.7, and for obesity OR=1.6, 95%CI: 1.0-2.4). These analyses suggest that liver dysfunction can be a predictor of impaired glucose metabolism.
