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  • 标题:Improved method for preparation of S9-activated heterocyclic amines
  • 本地全文:下载
  • 作者:Sakae Arimoto-Kobayashi ; Hikoya Hayatsu
  • 期刊名称:環境変異原研究
  • 印刷版ISSN:0910-0865
  • 电子版ISSN:1880-7054
  • 出版年度:2003
  • 卷号:25
  • 期号:2
  • 页码:77-81
  • DOI:10.3123/jems.25.77
  • 出版社:The Japanese Environmental Mutagen Society
  • 摘要:

    We investigated improved methods for the preparation of metabolically activated forms of heterocyclic amines referred to as ‘activated heterocyclic amines’. We also described the influence of pH on the metabolic activation of Trp-P-2, and on the stability and mutagenicity of the activated form of Trp-P-2.

  • 关键词:heterocyclic amine; activated Trp-P-2; pH; Ames test; pre-activated mutagen
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