Mindfulness is currently attracting a great deal of attention as a psychotherapeutic technique, which originated from Eastern meditation practices. It is defined as “paying attention in a particular way: on purpose, in the present moment, and nonjudgmentally” (Kabat-Zinn, 1994). This article reviews neuroscience studies of mindfulness, and genetic contributions to individual differences on the effect of the mindfulness intervention. Finally, we will discuss differences and similarities in neurobiological bases of emotion regulation between Eastern and Western people.