摘要：Three chemicals for use in household products, N-(cyclohexylthio)phthalimide (CTP), diethylene glycol mono- n -butyl ether acetate (DEGBEA) and di- n -butyl sebacate (DBS), were evaluated for their skin sensitization potency in a modified guinea pig maximization test (GPMT). CTP, which is used as a rubber chemical vulcanization retarder, produced strong skin sensitization: even at the lowest intradermal dose (0.01 ppm), 30% of animals in the dose group were sensitized. DEGBEA and DBS failed to elicit a positive skin reaction even at maximal concentrations of intradermal injection and elicitation. CTP-sensitized animals reacted neither to phthalimide, which has the basic chemical structure of CTP, nor to dithiocarbamates (zinc dimethyldithiocarbamate, zinc diethyldithiocarbamate and zinc di- n -butyldithiocarbamate), which are well-known allergens and are suspected to cross-react to CTP from the results of human patch test study. The data demonstrate that skin sensitization is readily induced in GPMT by CTP, but not by DEGBEA or DBS.
关键词：N-(cyclohexylthio)phthalimide;diethylene glycol mono-n-butyl ether acetate;di-n-butyl sebacate;skin sensitization;guinea pig maximization test
