摘要：Groups of 20 pregnant Wistar rats were treated orally with 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TMPDIB) from day 7 through 17 of gestation at doses of 0, 160, 400 or 1,000 mg/kg, and Caesarian sections were performed on day 20. Maternal toxicity in the 400 mg/kg group was evident by decreased food consumption. Numbers of fetuses, fetal body weights and degrees of ossification were not affected by TMPDIB, and no treatment-related fetal anomalies were noted in any dose groups. These findings indicate that the no-observed-adverse-effect level (NOAEL) for maternal and developmental toxicity was found to be 160 and 1,000 mg TMPDIB/kg/day, respectively.
