A microextraction method using a pipette tip type solid phase extraction (μSPE) device was developed for extraction of illicit drugs in human urine. Three types of pipette tips with monolithic SCX, C18 and C4 were compared with recovery of illicit drugs and metabolites such as methamphetamine, amphetamine, 3,4-methylendioxymethamphetamine, 3,4-methylendioxy-amphetamine, ketamine and norketamine, respectively.   The recovery was low (<64%) with SCX type pipette tip, however, C18 and C4 type tips were suitable to extract these drugs in high recovery (>86% and >81%, respectively) from 50 μL urine sample. And this extraction procedure was completed in five minutes.   Therefore, this microextraction method using C18 type μSPE device was useful for rapid and simple extraction of illicit drugs in small volume urine sample.