Semisub-Megafloats have been studied for an offshore infrastructure. It is clear through the previous studies that wind lift force acting on the deck of a Semisub-Megafloat is very important in high winds and waves such as typhoon conditions. In the present paper, the response characteristics of Semisub-Megafloats in winds and waves were investigated. The effects of wind lift force on the response of the structure was clarified and it was shown that column supported type VLFS is desirable from the point of view of wind lift force.