Reassurance seeking is a trait consisting of cognitional and behavioral aspects of seeking security from significant others which is associated with increased depression. This study investigated the relationship between reassurance seeking, temperament, and depression. Respondents ( N =209) filled out a questionnaire including scales of reassurance seeking, temperament (BIS/BAS), and depression. Structural Equation Modeling (SEM) using data from 192 respondents revealed that there were relationships between reassurance-seeking cognition, reassurance-seeking behavior, BIS, BAS—reward responsiveness, and depression. The results showed that reassurance seeking significantly enhanced depression, even when temperament was controlled.