标题：Simultaneous X-ray Diffraction-Differential Scanning Calorimetry and Physicochemical Characterizations of Spray Dried Drugs and Chitosan Microspheres
期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2015
卷号：13
期号：7
DOI：10.14456/vol13iss7pp%p
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：The aim of this study was to characterize the morphology and physicochemical properties of drug-chitosan spray dried particles (SDPs) which have been wildly used as a drug carrier. The SDP systems were composed of chitosan (CS, 45kDa, 87% degree of deacetylation) loaded with diclofenac sodium (DS) or theophylline anhydrous (TH) as model drugs. In the SPDs preparation process, the model drug was dissolved in distilled water and then dropped into the solution of CS dissolved in 0.5% acetic acid. The ratios of drug:CS were varied at 1:2, 1:4, 1:6, 1:8 and 1:10 ratios. The drug-CS suspension was spray dried then the products were collected and characterized. SEM and particle size analysis demonstrated that DS-CS SDPs were in irregular shape with size between 3.28-6.72 µm in diameter. In the other hand, TH-CS SDP were spherical and the size of TH-CS microspheres were between 3.64-4.28 µm in diameter. SEM images also showed that TH was completely encapsulated by CS at ratio of 1:8 over. From simultaneous DSC-XRD analysis, it was found that crystallinity of the drugs decreased when increasing of temperature. TH was altered from crystalline to amorphous state when CS portion was greater. In the FTIR spectra of the DS-CS SDP, new peak around 1700 cm-1 due to carboxylic moiety was observed which referred to some DS (salt form) changed to acid form. Proper portion of CS delayed the release of DS and TH.
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