期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2015
卷号：13
期号：3
DOI：10.14456/vol13iss4pp
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：Sputum smear and culture conversion are important indicators for effectiveness of treatment and infectivity of tuberculosis patients. Objective: Determine the factors associated with sputum conversion in patients with tuberculosis (TB) admitted at The Cuban Hospital (TCH) (Qatar). Method: A descriptive study of 64 patients with positive smear was carried out. It was collected patient characteristics at diagnosis (age, sex, smoking, alcohol, history of Diabetes mellitus or previous tuberculosis, and diagnostic's delay), nutritional indicators (Body mass index, Hemoglobin, lymphocytes count, iron, serum protein/albumin), platelet count, serial sputum and radiological findings. Analysis: Kaplan Meier survival and log rank test or Wilcoxon test were used. Significance level was set ≤ 0.05. Results: The 75% patients were below 39 years old (mean 32.61 years), male (78.1%), non-smokers (90.6%), no previous history of TB (96.9%), 17.2% had Diabetes mellitus. Diagnosis delay was over 30 days (65.6%). Minimum conversion was 5 days and maximum 115 days (median: 30 days). When compared survival curves according patient’s demographics, nutritional and radiological characteristics were not found statistically significant differences. Regarding bacterial load, 50 days after starting treatment, the two patient´s group with ≤1000 bacilli had negative sputum. Patients who had > 1500 bacilli, yet after 100 days of treatment, had positive sputum (p = 0.02). Differences between groups with lower and higher bacilli count was significant (p = 0.04). Conclusion: Our data has shown that the main factor related with the sputum conversion is the bacterial load, which will be useful to fix the case management of tuberculosis in Qatar.
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