期刊名称：Walailak Journal of Science and Technology (WJST)
印刷版ISSN：2228-835X
出版年度：2015
卷号：13
期号：3
DOI：10.14456/vol13iss1pp
语种：English
出版社：Institute of Research and Development, Walailak University.
摘要：A series of compound 6-Bromo-3-(6-substitutedphenyl)-2-(morpholinomethylamino) pyrimidin-4-yl)-2H-chromen-2-one (BT1M-T10M), 3(2-((piperidin-1-yl) methylamino)-6- (2-substitutedphenyl) pyrimidin-4-yl)-6-bromo-2H-chromen-2-one (BT1P-BT10P) have been synthesized from 3-(2-amino-6 -pyrimidin- 4-yl)-6- bromo- 2H-chromen-2-one (T1-T10). The structures of the synthesized compounds were elucidated by I.R., 1HNMR, elemental analysis and mass spectroscopic techniques. The synthesized compounds were screened for in-vivo anti-inflammatory activity at a dose of 50 mg/kg body weight by carrageenan induced rat paw edema method. Among them, compounds BT8M, BT4P, BT5P and BT7P exhibited significant anti-inflammatory. Compounds BT3M, BT9M, BT10M, BT9P and BT10P have shown highly significant anti-inflammatory activity. The remaining compounds have shown less anti-inflammatory activity comparable to that of standard drug diclofenac sodium.
关键词：Biological Sciences;Pyrimidine; Anti-inflammatory activity; Rat paw edema; Carragenan
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