The primary purpose of the study was to investigate the effect of job-related characteristics on the employees’ intent to leave the organization. In order to accomplish this purpose a survey questionnaire was adapted and administered to 750 employees of various commercial banks of Pakistan. Out of the 750 questionnaires administered 700 were received with a response rate of 93.33%. Structural Equation Modeling was applied using AMOS 16 software. The results revealed a highly significant effect of job characteristics on intent to leave the organization in the presence of the mediation of the four dimensions of organizational commitment. The results can prove to be useful for the human resource managers to review the job description and revise or redesign the job characteristics that would help the organizations to retain employees in the organization.