出版社：Japanese Society of Nutrition and Food Science
摘要：The patients with typical beriberi symptoms and with primary Perléche (fissure and erosion at the angle of the mouth) served as thiamine deficient and riboflavin deficient patients for this study. The serum protein pattern was examined by paperchromatography. The following results were obtained. 1) The serum proteins of the beriberi patients were of various grades, from normal level to high degree of hypoproteinemia. Edema, which is the main symptom of beriberi, is not necessarily related with the serum protein contents, and it can often been noticed even in patients with normal serum protein contents. In the treatment of edema, injection of thiamine as well as its derivatives (oral administration is the same) was very effective. In the cases of beriberi, edema with low serum protein level was not cured unless given large amounts of protein or amino acids together with thiamine. 2) Among riboflavin deficient patients including those who seemed to be healthy in general condition, their serum protein patterns were of various grades from normal level to hypoproteinemia. The serum protein patterns of patients who repeatedly suffered from riboflavin deficiency for many years were worse. The patients with normal protein pattern cannot be cured with riboflavin alone. Only large amount of good quality protein or amino acids togetherwith FAD injections were sufficiently effective.
