The range of analytical techniques in the field of Regional Science has grown enormously in the last decade; however, integration - of techniques and modelling frameworks - has not been a prominent feature until relatively recently. In this paper, a brief review of some early developments in integrated modelling will precede discussion of some of the current initiatives. An re-examination of a call for large scale modelling made by Boyce (1989) will be considered in the context of work in regional and interregional social accounting and computable general equilibrium models, especially in the developing world. The review will be illustrated by reference to research undertaken in Bangladesh, Korea and Indonesia and the resulting policy analyses conducted with these models.