In this study a methodology for setting up “the regional management center” is discussed aiming at effective and efficient promotios of desirable regional comprehensive development from social, economical and environmental viewpoints. Making effects to establish well-communicating system among all participants, the regional management center is aimed to be set up as an organization which undertakes planning and management works for the regional development projects which is authorized in the master plan of urban development. The participants are local residents, local industries, newly locating business enterprises and municipal agencies concerned to the development projects. It is generally desired that various discussions are to be prepared in each planing and management process through implementation of development projects in order to obtain consensus about planning and management contents among all the involved participants. In this study several proposals to promote regional development efficiently and effectively are discussed. Through this discussion the functional organization which undertakes research, analysis, planning, coordination, presentation and all other management works is recognized to be very important to promote various development projects effectively under proter consensus among all the involved participants. In those proposals various kinds of system with function which provides the participants planning and management information for discussion and decision-making about planning and management contents are discussed logically and theoretically by introducing mathematical planning models and system simulation models. In the final stage of this study some actual methodological effects are shown through case study for setting up the regional management center at Maihara-cho in the north-east region of Shiga-prefecture.