文章基本信息

标题：Social cognition impairment in Huntington's disease: neuropsychological and neuroimaging, two complementary approaches
作者：Marie Caillaud ; Béatrice Desgranges ; Christophe Verny 等
期刊名称：Revue de Neuropsychologie Neurosciences Cognitives et Cliniques
印刷版ISSN：2101-6739
电子版ISSN：2102-6025
出版年度：2015
卷号：7
期号：2
页码：109-116
DOI：10.1684/nrp.2015.0342
出版社：John Libbey Eurotext
摘要：Authors Marie Caillaud ¹ ² ³ ⁴ ⁵ Béatrice Desgranges ² ³ ⁴ ⁵ Christophe Verny ⁶ Philippe Allain ¹ ⁶ ⁷ * 1 Laboratoire de psychologie des Pays de la Loire (LPPL), EA 4638, France 2 Inserm, U1077, Caen, France 3 Université de Caen Basse-Normandie, UMR-S1077, Caen, France 4 École Pratique des Hautes Études, UMR-S1077, Caen, France 5 CHU de Caen, UMR-S1077, Caen, France 6 CHU d’Angers, Département de neurologie, Angers, France 7 CHU d’Angers, Centre mémoire de ressources et de recherches, Angers, France * Correspondance Key words: maladie de Huntington, cognition sociale, fonctions exécutives, neuro-imagerie DOI : 10.1684/nrp.2015.0342 Page(s) : 109-16 Published in: 2015 The ability to maintain interpersonal relationships, from both emotional and social perspectives, belongs to the concept of social cognition. This involves different processes such as the ability to understand and convey emotions, infer the mental states of others, know and understand social rules. Selective or full impairment of these processes can be found in various pathologies. This is the case in Huntington's disease, a rare genetic neurodegenerative disease, disturbing motor, cognitive, and neuropsychiatric functions. The purpose of this article is to review the current state of knowledge on social cognition disturbances in this disease, on one hand, from a cognitive point of view and on the other hand, in terms of morphological and functional (resting state and activation) brain imaging. The scarcity of investigations on social cognition in Huntington's patients hinders the accurate identification and quantification of their social cognition disturbances, the involvement of executive functions and the link between brain abnormalities and neuropsychological deficits observed in this pathology. However, we will present here the conclusions drawn from early research on this topic.
关键词：maladie de Huntington; cognition sociale; fonctions exécutives; neuro-imagerie