文章基本信息
- 标题：Synthesis of Antifungal Evaluation of 2 H -[1,2,3]Triazolo[4,5- g ]isoquinoline-4,9-diones
- 本地全文：下载
- 作者：Chung-Kyu Ryu ; Sun Young Oh ; Soo Jung Choi 等
- 期刊名称：Chemical and Pharmaceutical Bulletin
- 印刷版ISSN：0009-2363
- 电子版ISSN：1347-5223
- 出版年度：2014
- 卷号：62
- 期号：11
- 页码：1119-1124
- DOI：10.1248/cpb.c14-00527
- 出版社：The Pharmaceutical Society of Japan
- 摘要：
2 H -[1,2,3]Triazolo[4,5- g ]isoquinoline-4,9-diones and 2 H -[1,2,3]triazolo[4,5- g ]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a , 3b , 3g , and 3h completely inhibited the growth of all fungal species tested at the MIC level of 0.8–12.5 µg/mL. The results suggest that 2 H -[1,2,3]triazolo[4,5- g ]isoquinoline-4,9-diones could be antifungal agents.
- 关键词：antimicrobial; antifungal; fungus; 2 H -[1,2,3]triazolo[4,5- g ]isoquinoline-4,9-dione
