期刊名称：Journal of Nutritional Science and Vitaminology
印刷版ISSN：0301-4800
电子版ISSN：1881-7742
出版年度：2014
卷号：60
期号：3
页码：159-166
DOI：10.3177/jnsv.60.159
出版社：Center for Academic Publications Japan
摘要：Declining renal function is commonly observed with age. Obesity induced by a high-fat diet (HFD) may reduce renal function. Korean red ginseng (KRG) has been reported to ameliorate oxidative tissue injury and have an anti-aging effect. This study was designed to investigate whether HFD would accelerate the D -galactose-induced aging process in the rat kidney and to examine the preventive effect of KRG on HFD and D -galactose-induced aging-related renal injury. When rats with D -galactose-induced aging were fed an HFD for 9 wk, enhanced oxidative DNA damage, renal cell apoptosis, protein glycation, and extracellular high mobility group box 1 protein (HMGB1), a signal of tissue damage, were observed in renal glomerular cells and tubular epithelial cells. However, treatment of rats with HFD- plus D -galactose-induced aging with KRG restored all of these renal changes. Our data suggested that a long-term HFD may enhance D -galactose-induced oxidative renal injury in rats and that this age-related renal injury could be suppressed by KRG through the repression of oxidative injury.
关键词：age-related renal injury; D -galactose;high-fat diet;Korean red ginseng;oxidative stress
