The aim of the study is to identify opportunities and constraints of the development of companies whose business is based on the exploitation of natural resources resulting from their location in areas of natural value. The study area consisted of 40 municipalities. Five companies were selected for the study in each municipality. The study used the method of diagnostic survey using a questionnaire interview. The results obtained give rise to a finding that economic activity based on the use of local natural resources, taking into account the need to protect the natural environment, is a legitimate direction and an opportunity for the development of local economies of areas of natural value. However, given the limitations of economic activities in natural valuable areas, it requires support, mainly with information and finance. The most important limitations of economic activities in natural valuable areas include the lack of preferential financial instruments, difficulties of the investment process and the lack of financial compensation for profits lost due to the location.