期刊名称：Revista Internacional de Contaminación Ambiental
印刷版ISSN：0188-4999
出版年度：1992
卷号：8
期号：2
页码：73-76
语种：English
出版社：Centro de Ciencias de la Atmósfera
摘要：Ovatifolin acetate (OA), a sesquiterpenic lactone has been isolated from Podanthus ovatifolius Lag. Compositae. When tested in standard tests in KB cells of human epidermoid nasopharingeal carcinoma, it showed antineoplastic activity. Since these drugs are well known to induce genetic damage the genotoxic activity of OA was evaluated using the micronucleus test in mice with male Balb/c mice. OA showed a cytotoxic effect by modifying cell proliferation kinetics of mouse bone marrow erythrocytes and also increased micronucleated cells.
其他摘要：Ovatifolin acetate (OA), a sesquiterpenic lactone has been isolated from Podanthus ovatifolius Lag. Compositae. When tested in standard tests in KB cells of human epidermoid nasopharingeal carcinoma, it showed antineoplastic activity. Since these drugs are well known to induce genetic damage the genotoxic activity of OA was evaluated using the micronucleus test in mice with male Balb/c mice. OA showed a cytotoxic effect by modifying cell proliferation kinetics of mouse bone marrow erythrocytes and also increased micronucleated cells.
关键词：antineoplastic effects; ovatifolin; sesquiterpene lactone; genotoxicity; micronucleus test
