期刊名称：Revista Internacional de Contaminación Ambiental
印刷版ISSN：0188-4999
出版年度：1996
卷号：12
期号：2
页码：83-88
语种：Spanish
出版社：Centro de Ciencias de la Atmósfera
摘要：Two antiprotozoal and antibacterial compounds, metronidazole and furazolidone, were tested for their genotoxic effects in somatic and male germ line cells of Drosophila melanogaster following chronic exposures of 2nd. and 3rd. instar larvae. Larvae carrying the recessive genetic markers mwh and flr 3 in a high bioactive background were tested for genotoxic effects in the somatic cells (wing primordia). To study the genotoxic effects of these compounds in the male germ line cells, the sex-linked recessive lethal test was performed using the Basc and Oregon-R strains. The results show that metronidazole is only genotoxic at the highest testable concentration both in the somatic and germ line cells whereas furazolidone is genotoxic even at lower concentrations.
其他摘要：Two antiprotozoal and antibacterial compounds, metronidazole and furazolidone, were tested for their genotoxic effects in somatic and male germ line cells of Drosophila melanogaster following chronic exposures of 2nd. and 3rd. instar larvae. Larvae carrying the recessive genetic markers mwh and flr3 in a high bioactive background were tested for genotoxic effects in the somatic cells (wing primordia). To study the genotoxic effects of these compounds in the male germ line cells, the sex-linked recessive lethal test was performed using the Basc and Oregon-R strains. The results show that metronidazole is only genotoxic at the highest testable concentration both in the somatic and germ line cells whereas furazolidone is genotoxic even at lower concentrations.
