期刊名称：Revista Internacional de Contaminación Ambiental
印刷版ISSN：0188-4999
出版年度：1993
卷号：9
期号：2
页码：71-88
语种：English
出版社：Centro de Ciencias de la Atmósfera
摘要：The influence of non-scientific factors on risk-assessment in the regulatory context is discussed. On the purely technical level, most controversy when dealing with data interpretation has been centered around certain types of tumors caused by exposure to non-genotoxic agents in the rodent, and which many scientists consider to be of doubtful relevance to man. The reasons for decreased reliance on such toxicological findings are high spontaneous background levels and/or mechanistic considerations. Such tumors include target organs like liver, bladder, forestomach, renal tubuli, as well as certain endocrine associated tumors, like those of the thyroid, mammary glands, pituitary, and adrenal glands (phaeochromocytomas). While discussing examples of controversial experimental carcinogens, the assessment by international organizations as well as regulatory decisions made by different national agencies in Europe and North America are presented.
其他摘要：The influence of non-scientific factors on risk-assessment in the regulatory context is discussed. On the purely technical level, most controversy when dealing with data interpretation has been centered around certain types of tumors caused by exposure to non-genotoxic agents in the rodent, and which many scientists consider to be of doubtful relevance to man. The reasons for decreased reliance on such toxicologicalfindings are high spontaneous background levels and/or mechanistic considerations.Such tumors include target organs like liver, bladder, forestomach, renal tubuli, as well as certain endocrine associated tumors, like those of the thyroid, mammary glands,pituitary, and adrenal glands (phaeochromocytomas).While discussing examples of controversial experimental carcinogens, the assessment by international organizations as well as regulatory decisions made bydifferent national agencies in Europe and North America are presented.
